Several postdoctoral positions are available in Drosophila labs (Thomas Neufeld, Hiroshi Nakato, and Michael O'Connor) at the Developmental Biology Center, the University of Minnesota.
The Neufeld lab is interested in mechanisms of autophagy regulation by nutrient-dependent signaling in Drosophila. Current projects focus on how autophagosome maturation, acidification and fusion are regulated by the mTOR pathway, and how nutrient release from the larval fat body supports development of peripheral tissues.
The Nakato lab studies the molecular mechanisms of the regeneration termination using the Drosophila intestinal stem cell model. The failure of proper termination of tissue regeneration results in the emergence of unwanted cells, leading to a high risk of cancer. However, it is poorly understood how a damaged tissue senses when to terminate the regeneration process and inactivates stem cell mitotic activity. The project focuses on the roles the microRNA-mediated network in stem cell control during regeneration termination.
The O’Connor lab is interested in understanding the physiological mechanisms by which tissues coordinate their growth and remodeling during development. One project seeks to identify the upstream signals and downstream effectors in the neuroendocrine pathway that controls initiation of metamorphosis. A second area of study is to elucidate the network architecture of Activin signaling that controls Drosophila body size, tissue scaling and metabolism in response to various environmental inputs including nutrition, stress, temperature, pathogens, and population density. Previous experience with either molecular genetics, bioinformatics, metabolic measurements, optical/EM imaging, and/or biochemical methods is preferred.
The Developmental Biology Center (https://cbs.umn.edu/academics/departments/gcd/dbc) provides a rich environment for interaction with a large group of investigators using diverse approaches and systems to study all aspects of development. Postdoctoral trainees at the University of Minnesota are offered a supportive mentored environment with opportunities for professional development (https://pda.umn.edu). DBC is centered in the Twin Cities of Minneapolis and Saint Paul, which consistently ranks as one of the top places to live in the U.S. and is a hub for biotech and biopharmaceutical companies.
All positions are immediately available (with flexible start date). Interested individuals should email Tom Neufeld (email@example.com), Hiroshi Nakato (firstname.lastname@example.org), or Mike O'Connor (email@example.com).